TB-500

What is TB-500

TB-500 is a synthetic peptide fragment derived from the naturally occurring protein Thymosin Beta-4 (Tβ4) — one of the most abundant thymic peptides found in mammalian tissues. It represents the active region of Thymosin Beta-4 and reproduces its biological and regenerative properties, being more stable and easier to produce.

Thymosins are present in multiple tissues and play a role in cell protection, wound healing, and regeneration. TB-500 regulates actin dynamics, a key process for cell migration, angiogenesis, and tissue remodeling. Due to these properties, it is widely used to accelerate recovery after injuries, reduce inflammation, and improve flexibility of connective tissues.

Main effects of TB-500

💪 Accelerates recovery of muscles, tendons, ligaments, and joints

🧬 Promotes cell migration and stem cell activation

🔥 Reduces inflammation and prevents fibrosis

🩸 Stimulates angiogenesis and improves tissue oxygenation

💓 Supports heart tissue regeneration and vascular growth

🧠 Contributes to neural protection and recovery

💇‍♂️ Stimulates hair follicle activity and hair growth

👁️ Promotes corneal healing and alleviates dry eye symptoms

How to take TB-500

Administration

• Route: Subcutaneous or intramuscular injection
• Solvent: Bacteriostatic water
• Injection sites: Rotated (abdomen, thigh, deltoid)
• Storage: Reconstituted solution kept refrigerated at 2–8 °C

Dosage

Loading phase:

• 2–6 mg per week, divided into 2 injections
• Duration: about 4 weeks

Maintenance phase:

• 2–4 mg per week, divided into 2 injections
• Duration: 1–2 months

Alternative pattern:

• Week 1: 10 mg total (1–2 mg daily)
• Weeks 2–6: 5 mg per week, divided doses
• Maintenance: 10 mg monthly (2 mg every 6 days)

Possible side effects

• Mild redness or discomfort at the injection site
• Temporary fatigue or headache
• Local swelling or warmth
• Very rarely, allergic skin reaction

Contraindications

• Active malignancies (angiogenic stimulation)
• Pregnancy or breastfeeding
• Autoimmune disorders
• Hypersensitivity to peptide compounds

How to store

• Powder form: Below 25 °C, away from light and humidity
• Reconstituted solution: Refrigerate at 2–8 °C, do not freeze
• Use within 30 days after mixing

How does TB-500 work

TB-500 functions by binding to G-actin, a protein essential for the formation of the cellular cytoskeleton. Through this interaction, it regulates actin polymerization and cell migration, both critical steps in tissue regeneration and repair.

1. Regenerative activity

The peptide enhances mobilization of stem and progenitor cells to damaged areas, promoting angiogenesis and formation of new tissue structures. It accelerates healing and reduces scar formation by limiting excessive fibroblast activity.

2. Anti-inflammatory effects

TB-500 moderates cytokine response and inflammatory cascades, lowering oxidative stress and protecting cells from apoptosis in injured tissues.

3. Cardiovascular and neurological action

In cardiac tissues, it supports myocyte survival and angiogenic repair after ischemic events. In the nervous system, it promotes axon regeneration, synaptic stability, and recovery of motor functions.

4. Additional systemic roles

• Enhances tissue elasticity and connective fiber integrity
• Reduces the risk of adhesion formation after trauma
• Stimulates hair follicle regeneration and corneal healing