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What is tamoxifen Tamoxifen is a selective estrogen receptor modulator (SERM) belonging to the triphenylethylene group. It acts as both an estrogen antagonist and partial agonist, depending on the tissue type. In most tissues — including the breast, hypothalamus, and pituitary gland — it blocks estrogen receptors, while in bone tissue, tamoxifen activates estrogen receptors, helping to preserve bone density and prevent osteoporosis. Originally developed for breast cancer therapy, tamoxifen is ..