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What is oxandrolone Oxandrolone is a synthetic anabolic steroid first introduced in the 1960s. It is derived from dihydrotestosterone (DHT), but modified to be less androgenic and more anabolic, which makes it one of the mildest and safest oral steroids available. Originally created for medical use — including muscle wasting, burn recovery, and bone loss — it was later adopted by athletes for its ability to preserve lean tissue and enhance muscle tone during calorie restriction. Unlike many ..