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What is Melanotan II Melanotan II is a synthetic peptide analogue of the natural hormone alpha-melanocyte-stimulating hormone (α-MSH). It was originally developed to stimulate skin pigmentation and protect against ultraviolet (UV) radiation damage. By mimicking α-MSH, it activates melanocortin receptors, promoting melanin production in the skin — the pigment responsible for tanning. Beyond tanning, studies have shown that Melanotan II can also influence sexual function and appetite, due to i..