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What is clomiphene citrate? Clomiphene citrate is a selective estrogen receptor modulator (SERM) originally developed in the 1960s to treat female infertility. It acts on the hypothalamic–pituitary–gonadal axis, stimulating the release of gonadotropins — luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In medicine, clomiphene is used to induce ovulation in women and improve sperm production in men with low fertility. In sports, it is commonly used during post-cycle therapy (P..